(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester KPT185

Name	KPT-185
Synonyms	CS-844 KPT185 KPT-185 (Z)-Isopropyl 3-(3-(3-methoxy-5-(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)acrylate (2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester 2-Propenoic acid, 3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 1-methylethyl ester, (2Z)- (2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester KPT185
CAS	1333151-73-7

Molecular Formula	C16H16F3N3O3
Molar Mass	355.31
Solubility	DMSO 71 mg/mL Water <1 mg/mL Ethanol 71 mg/mL
Storage Condition	-20℃
In vitro study	KPT-185 significantly inhibited leukemia cell proliferation, with IC50 from 100 nM to 500 nM, and induced cell cycle arrest and apoptosis in AML cell lines and primary AML cells. KPT-185 reduced CRM1 protein levels and showed significant nuclear accumulation of CRM1 cargo protein. KPT-185 also inhibits proliferation and promotes apoptosis of pancreatic cancer cells without affecting human pancreatic ductal epithelial cells. KPT-185 significantly inhibited leukemia cell proliferation with IC50 from 100 nM to 500 nM, and induced cell cycle arrest and apoptosis in AML cell lines and primary AML cells. KPT-185 reduced CRM1 protein levels and showed significant nuclear accumulation of CRM1 cargo protein. KPT-185 also inhibits proliferation and promotes apoptosis of pancreatic cancer cells without affecting human pancreatic ductal epithelial cells.

KPT-185 is a selective CRM1 inhibitor.

Last Update：2022-10-16 17:41:25

biological activity	KPT-185 is a selective CRM1 inhibitor. KPT-185 is an effective and selective CRM1 inhibitor, which can inhibit the growth of some NHL cells and induce apoptosis. IC50 is about 25 nM.
in vitro study	KPT-185 significantly inhibit leukemia cell proliferation, IC50 from 100 nM to 500 nM, and induce cell cycle arrest and apoptosis of AML cell lines and primary AML cells. KPT-185 reduced CRM1 protein level and showed significant nuclear accumulation of CRM1 cargo protein. KPT-185 also inhibits proliferation and promotes apoptosis of pancreatic cancer cells without affecting human pancreatic ductal epithelial cells. KPT-185 significantly inhibited leukemia cell proliferation, IC50 from 100 nM to 500 nM, and induced cell cycle arrest and apoptosis of AML cell lines and primary AML cells. KPT-185 reduced CRM1 protein level and showed significant nuclear accumulation of CRM1 cargo protein. KPT-185 also inhibits proliferation and promotes apoptosis of pancreatic cancer cells without affecting human pancreatic ductal epithelial cells.
target	TargetValue CRM1
Target	Value

Last Update：2024-04-09 21:04:16

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CAS: 1333151-73-7
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Product Name: KPT-185 Visit Supplier Webpage Request for quotation
CAS: 1333151-73-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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(2Z)-3-[3-[3-Methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 1-methylethyl ester KPT185 Request for Quotation